JC Virus Agnoprotein Colocalizes with Tubulin
نویسندگان
چکیده
منابع مشابه
The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin
Virus infections can result in a range of cellular injuries and commonly this involves both the plasma and intracellular membranes, resulting in enhanced permeability. Viroporins are a group of proteins that interact with plasma membranes modifying permeability and can promote the release of viral particles. While these proteins are not essential for virus replication, their activity certainly ...
متن کاملJC Virus Encephalopathy Is Associated with a Novel Agnoprotein-Deletion JCV Variant
JC virus encephalopathy (JCVE) is a newly described gray matter disease of the brain caused by productive infection of cortical pyramidal neurons. We characterized the full length sequence of JCV isolated from the brain of a JCVE patient, analyzed its distribution in various compartments by PCR, and determined viral gene expression in the brain by immunohistochemistry(IHC). We identified a nove...
متن کاملPhosphorylation mutants of JC virus agnoprotein are unable to sustain the viral infection cycle.
Many eukaryotic and viral regulatory proteins are known to undergo posttranslational modifications including phosphorylation, which plays a critical role in many aspects of cell function. Previous studies from our and other laboratories indicated that the JC virus (JCV) late regulatory protein, agnoprotein, plays an important role in the JCV life cycle. Agnoprotein contains several potential ph...
متن کاملJC virus agnoprotein inhibits in vitro differentiation of oligodendrocytes and promotes apoptosis.
Productive infection of oligodendrocytes, which are responsible for the formation of myelin sheath in the central nervous system, with the human neurotropic virus JC virus (JCV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). In addition to encoding T antigen and the capsid proteins, which are produced at the early and late phases of the infection cycle,...
متن کاملDetection of JC polyomavirus DNA sequences and cellular localization of T-antigen and agnoprotein in oligodendrogliomas.
PURPOSE Productive infection of the human neurotropic polyomavirus JCPyV in oligodendrocytes leads to the development of progressive multifocal leukoencephalopathy, a fatal demyelinating disorder of the central nervous system. In addition to its role in viral infection, JCPyV T-antigen can transform cells in vitro and induce tumors in experimental animals in the absence of viral DNA replication...
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ژورنال
عنوان ژورنال: Journal of Neurovirology
سال: 2003
ISSN: 1355-0284,1538-2443
DOI: 10.1080/13550280390195333